Compiled By Jessica Oesterheld,
M.D.
This table is an abridged guide to Cytochrome variability. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.
Last Update: November 1, 2007
Characteristic |
|
1A2 |
2A6 |
2B6 |
2C9 |
2C19 |
2D6 |
2E1 |
3A |
Percent of Total CYPs |
|
10-15% |
4% |
1-10%% |
15-20% |
5% |
2.5% |
7% |
30-40% |
Inter-individual Variability |
|
40 fold |
30 fold |
50 fold |
25-100 fold |
|
2.5 fold |
7 fold |
40 fold |
Common Polymorhphism |
|
1A2*1F |
|
|
2C9*2 |
2C19*2 |
2D6*2 |
|
|
|
|
1A2*1C |
|
|
2C9*3 |
2C19*3 |
2D6*4 |
|
|
|
|
|
|
|
2C9*5 |
2C19*4 |
2D6*5 |
|
|
|
|
|
|
|
|
2C19*5 |
2D6*10 |
|
|
|
|
|
|
|
|
2C19*17 |
2D6*17 |
|
|
|
|
|
|
|
|
|
2D6*41 |
|
|
|
|
|
|
|
|
|
|
|
|
Slow Metabolizers
|
|
|
|
|
|
|
|
|
|
|
Caucasians |
|
20% |
|
18% |
2-4% |
7-10% |
|
|
|
African Americans |
|
2% |
|
1% |
1% |
6-8% |
|
|
|
Asians |
|
|
|
1% |
|
1-2% |
|
|
|
Japanese |
|
|
|
1% |
18-23% |
|
|
|
|
Chinese |
|
|
|
|
5-17% |
|
|
|
|
|
|
|
|
|
|
|
|
|
Ultrafast Metabolizers
|
|
|
|
|
|
|
|
|
|
|
Caucasians |
|
|
|
|
|
1% |
|
|
|
Asians |
|
|
|
|
|
1% |
|
|
|
Swedes |
|
|
|
|
18% |
|
|
|
|
Chineses |
|
|
|
|
4% |
|
|
|
Decreases with Age
|
|
Same as adult or dec |
? |
? |
Dec |
Dec |
No |
Conflictual results |
Same as adult or dec |
Gender male/female |
|
Higher men |
|
|
Equal |
Equal |
Equal |
Slightly higher men with
some drugs ? effect on hepatic blood flow |
Slightly higher women |
| * Based on data from Rendic S, DiCarlo FJ,
Human cytochrome P450 enzymes: a status report summarizing their reactions,
substrates, inducers and inhibitors. Drug metab Reviews 29:413-580,1997
and Abernethy and Flockhart: Molecular basis of cardiovascular drug
metabolism: implications for predicting clinically important drug
interactions. Circulation 2000 101:1749-53 Cotreau MM, von Moltke
LL, Greenblatt DJ.The influence of age and sex on the clearance of
cytochrome P450 3A substrates. Clin Pharmacokinet. 2005;44(1):33-6
0Parkinson A, Mudra DR, Johnson C, Dwyer A, Carroll KM. effects of
gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme
activity in human liver microsomes and inducibility in cultured human
hepatocytes.Toxicol Appl Pharmacol. 2004 Sep 15;199(3):193-209 and
Benedetti MS, Whomsley R et al: Drug metabolism in the pediatric population
and in the elderly Drug Discovery Today 60:3-12, 2007 |
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