CYP and UGT Metabolic Route Development in Childhood

Compiled By Jessica Oesterheld, M.D.

This table is an abridged guide to CYP and UGT metabolic route development in childhood. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

Last Update: May 16, 2008

Metabolic Route

FETUS

DEVELOPMENT IN CHILDHOOD

CYP1A2 becomes active after the 4th or 5th month after birth; formula feeding accelerate maturation
CYP2A6
CYP2B6
CYP2C8
CYP2C9 becomes active in first few weeks after birth;50% reach adult values by 5 months;exceeds adult activity from 3-10 years; reaches adult values after puberty
CYP2C19 becomes active in first few weeks after birth; reaches adult values about 10 years
CYP2D6 becomes active first few weeks after birth;reaches adult values by 10 years
CYP2E1 gradually develops over first few months after birth
CYP3A4 appears in first few weeks after birth; may be lower activity from 5-15 years; formula feeding accelerates maturation
CYP3A5 present present in 20% of population
CYP3A7 predominant CYP fades after 2 weeks post natal, then present in 20% population
acetylation reaches adult levles by 2-4 years
sulfation predominant Phase 2 reaches adult levels by 2-4 years
UGT1A1 immature at birth, responsible for hyperbilirubinemia; reaches adult values 3-6 months after birth
UGT2B7 immature at birth; reaches adult values 3-6 months after birth
UGT1A9 develops only after second year after birth
UGT2B4 develops only after second year after birth
Reference PubMed PMID:17065585