Changes in Clearance During Pregnancy for some CYPs and UGTs

Compiled By Jessica Oesterheld, M.D.

This table is an abridged guide to CYPs and UGTs during pregnancy. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

Last Update: May 16, 2008

Changes in Clearance

1st semester 2nd semester 3rd semester
CYP 1A2 reduced 33% reduced 49% reduced 65%
CYP2A6 increased 54% increased 54%
CYP2B6
CYP2C8
CYP2C9 no change no change increased 20%
CYP2C19 reduced 50% reduced 50%
CYP2D6 increased 26% increased 35% increased 48%
CYP2E1
CYP3A4 increased 35-38% increased 35-38% increased 35-38%
UGT1A4 increased 200% increased 200% increased 300%
UGT2B7 indeterminate
acetylation indeterminate no change no change
xanthin oxidase no change no change no change