Compiled By Jessica Oesterheld, M.D.
This table is an abridged guide to CYPs and UGTs during pregnancy. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.
Last Update: May 16, 2008
Changes in Clearance
|1st semester||2nd semester||3rd semester|
|CYP 1A2||reduced 33%||reduced 49%||reduced 65%|
|CYP2A6||increased 54%||increased 54%|
|CYP2C9||no change||no change||increased 20%|
|CYP2C19||reduced 50%||reduced 50%|
|CYP2D6||increased 26%||increased 35%||increased 48%|
|CYP3A4||increased 35-38%||increased 35-38%||increased 35-38%|
|UGT1A4||increased 200%||increased 200%||increased 300%|
|acetylation||indeterminate||no change||no change|
|xanthin oxidase||no change||no change||no change|