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Changes in Clearance During Pregnancy for some
CYPs and UGTs

Compiled By Jessica Oesterheld, M.D.

This table is an abridged guide to CYPs and UGTs during pregnancy. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

Last Update: May 16, 2008

Changes in Clearance

  1st semester 2nd semester 3rd semester
CYP 1A2 reduced 33% reduced 49% reduced 65%
CYP2A6   increased 54% increased 54%
CYP2B6      
CYP2C8      
CYP2C9 no change no change increased 20%
CYP2C19   reduced 50% reduced 50%
CYP2D6 increased 26% increased 35% increased 48%
CYP2E1      
CYP3A4 increased 35-38% increased 35-38% increased 35-38%
UGT1A4 increased 200% increased 200% increased 300%
UGT2B7     indeterminate
acetylation indeterminate no change no change
xanthin oxidase no change no change no change


GeneMedRx has not been reviewed or approved by the United States Food and Drug Administration and cannot be used to diagnose or treat any disease or other health condition.

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