Compiled By Jessica Oesterheld, M.D.

This table is an abridged guide to CYPs and UGTs during pregnancy. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

Last Update: May 16, 2008

Changes in Clearance

1st semester 2nd semester 3rd semester
CYP 1A2 reduced 33% reduced 49% reduced 65%
CYP2A6 increased 54% increased 54%
CYP2B6
CYP2C8
CYP2C9 no change no change increased 20%
CYP2C19 reduced 50% reduced 50%
CYP2D6 increased 26% increased 35% increased 48%
CYP2E1
CYP3A4 increased 35-38% increased 35-38% increased 35-38%
UGT1A4 increased 200% increased 200% increased 300%
UGT2B7 indeterminate
acetylation indeterminate no change no change
xanthin oxidase no change no change no change