Cytochrome P-450 (CYP) Metabolism Reference Table
Compiled By Jessica Oesterheld, M.D.
This is an illustrative guide to the cytochrome P450 contribution to drug interactions likely for medication pairs that are substrates, inhibitors or inducers of the same enzyme. More than one-half of patients also carry genetic variations in CYP 1A2, 2C9, 2C19, and 2D6 genes that can dramatically alter patient drug exposures, and for which DNA testing can be ordered. The GeneMedRx drug interaction software provides a more complete and automated tool for comprehensive medication management, with optional input of genetic variations, OTCs, foods, herbals, and other relevant patient factors to produce drug interaction reports based on the cumulative effect of all known drug metabolism variables. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations. Last
Update: May 16, 2008
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CYTOCHROME P450 DRUG-INTERACTIONS SUBSTRATES TABLE
Substrates (primary enzyme for metabolism)
|
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1A2 |
2B6 |
2C8 |
2C19 |
2C9 |
2D6 |
3A4,5,7 |
|
Psychotropics: Other: |
bupropion |
{amiodarone} |
Psychotropics: Anticonvulsants: Proton Pump Others: |
Psychotropics: NSAIDS: Hypoglycemics: Others: |
Psychotropics: Antihistamines: Beta Blockers: >Cough Medicines Opiates:
|
Psychotropics: Drugs of abuse/ Antibiotics/ Antifungals: Anticonvulsants: Antihistamines: |
Asthma >Calcium Channel Hormones/chemo-therapeutics: Others: |
CYTOCHROME P450 DRUG-INTERACTIONS INHIBITORS TABLE
Inhibitors (reduces or blocks the ability of the enzyme to metabolize the substrates) |
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1A2 |
2B6 |
2C8 |
2C19 |
2C9 |
2D6 |
3A4,5,7 |
acyclovir |
clopidogrel |
gemfibrozil |
artemisinin |
amiodarone |
amiodarone |
amiodarone |
CYTOCHROME P450 DRUG-INTERACTIONS INDUCERS TABLE
Inducers (increases the ability of the enzyme to metabolize the substrates) |
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1A2 |
2B6 |
2C8 |
2C19 |
2C9 |
2D6 |
3A4,5,7 |
carbamazepine |
lopinavir/ritonavir |
rifampin |
gingko biloba |
aprepitant-long term |
?rifampin |
aprepitant -long term |