Drug-Drug Interaction Software
By Clinicians, for Clinicians
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"Using the P450 Interactions program, I was immediately able to resolve several complicated medication problems in three of my patients. The program is a perfect complement to the cytochrome P450 DNA testing I've been using for the last two years."

- Frank J. Genova, MD

Comprehensive Solution
GeneMedRx is the first software tool available to prescribers that predicts potential drug-drug and drug-gene interaction risk based on both cytochrome P450 metabolism and genetic testing. This information helps physicians gain enhanced understanding of metabolism-based adverse drug interactions and/or lack of efficacy.

GeneMedRx is the upgraded, pharmacogenetics-ready version of Mental Health Connections P450 Interactions program. The most extensive coverage of cytochrome P450s available and in use by physicians since 1997.

Regularly Updated
Constantly updated to keep pace with the dozens of relevant reports appearing each month. The database currently contains:

• 2000 Drugs and Metabolites
• 4500 PubMed Links
• 2000 Unique Notes
• 1500 Substrates
• 1000 Inhibitors and Inducers

Algorithm Driven
Unlike other DDI programs GeneMedRx uses an algorithm to predict and weight DDIs for drug combinations not reported in the literature.

Designed For Accessibility

• Available from any computer with Internet access.
• Colors and icons highlight interactions of concern.
• Optional entry of patient's genetic profile provides information based on drug-gene interactions
• Program allows for what-if scenarios.
• A clinical confidence rating is given for those predictions that are supported by clinical data.
• Not unduly alarmist.
• Results are presented in a simple form with detailed notes and references readily available.

How GeneMedRx Works

1. 1. Input patient prescription, OTC, herbal medicine regimens, food intakes, patient factors (pregnancy, cigarette smoking, etc.), and chemical exposures. If available, input patient's pharmacogenetic test results (For information on obtaining this testing, call Genelex at 800-523-6487 or visit www.healthanddna.com/drugreactiontest.html).

2. Scan the results for potential DDIs based on the metabolism of the drugs in question. Please note that results do not include the minority of DDIs for which metabolism is not understood.

3. Determine the effect removing or adding a particular drug has on the predicted change.

4. If needed, pick an alternate drug or dosage based on the predicted change profile

Case example

Jane's physician added paroxetine to her other meds after consulting GeneMedRx to determine there were no significant interactions noted. When Jane experienced nausea and sleeplessness, pharmacogenetic testing was ordered. Jane is a CYP2D6 poor metabolizer with a genotype of *4/*4. She was normal for other CYP genotypes. Her physician again consulted GeneMedRx and found that paroxetine was a high-risk medication for Jane's genotype. By querying the program he found that citalopram, a CYP2C19 substrate, might be safer for Jane.

Program Authors

Jessica R. Oesterheld, M.D., a practicing psychiatrist and educator, is a frequent author and lecturer on metabolism-based pharmacology in adults and children. Her interest arose from clinical experiences with adverse drug reactions caused by CYP based drug interactions.

Neil B. Sandson, M.D., is Director of the Division of Education and Residency Training at Sheppard Pratt Health System.

David N. Osser, M.D., is a clinical psychopharmacology consultant and a member of the International Psychopharmacology Algorithm Project.

Ordering Software
The software is available as an internet subscription. Call 877 431-4362 for further details or order online.

GeneMedRx has not been reviewed or approved by the United States Food and Drug Administration and cannot be used to diagnose or treat any disease or other health condition.