P-glycoprotein (PGP) Table – the Effect of Drugs and Foods

Compiled By Jessica Oesterheld, M.D.

This table is an abridged guide to PGPs. For an introduction to PGPs, click here. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

Last Update: May 22, 2009
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Not substrates

substrates

inhibitors

NOT inhibitors

inducers

albendazole  11901088 actinomycin D 11497241 alfentanil 11964599 albendazole  11901088 ?amitriptyline  10831014
alfentanil 11964599 aldosterone (Delph 2000) amiloride Watkins fluconazole 11751127 amprenavir Zhou 2008
amantadine 11602674 alpha-methyldigoxin  11284449 amiodarone 11231118 fluvastatin 17064205 ASA 11205285
bezafibrate 14698041 amiloride Watkins amitripyline 10408903 isosorbide 12499648 bromocriptine Zhou 2008
bupropion 18239278 amitriptyline Watkins 18239278 astemizole Zhou 2008 levetiracetam 9929511 chlorambucil Zhou 2008
chlorpheniramine 11602674 amoxicillin 2213563 atovaquone 11459198 (modest) pravastatin 11902809 cisplatin Zhou 2008
chlorpromazine 11602674 amprenavir  11242145 atorvastatin 11250868 zolpidem 12469329 clotrimazole 12489979
clozapine  10831014 atorvastatin 12406646 azelastine 11231118   colchicine Zhou 2008
cortexolone  12379510 beta-acetyldigoxin 11284449 azidopine Watkins   cyclosporine Zhou 2008
fenbibrate 14698041 bisantrene 11497241 azithromycin 18027988   delavirdine  12180537
fentanyl 11964599 bunitrolol 12406646 bepidil Zhou 2008   daunorubicin Zhou 2008
fluconazole 11751127 carbamazepine 11733711 biricodar11895894++   dexamethasone 12451243
flunitrazepam  10831014 celiprolol  12406646 bromocriptine 11861816   doxorubicin 11311122
fluoxetine  10831014 cetirizine 16364611 carbamazepine 12954800   efavirenz 12180537
gemfribosil 14698041 chloroquine Watkins carvedilol 11895100   erythromycin Zhou 2008
haloperidol  10831014 chlorpromazine Watkins chloroquine Watkins   etoposide Zhou 2008
itraconazole 11602674 cimetidine  9862768 chlorpromazine  11747345   flurouracil Zhou 2008
ketoconazole 11602674 citalopram 18239278 clarithromycin 10901387   hydroxyurea Zhou 2008
lidocaine 11602674 ciprofloxacin 9283689 cyclosporin 10586385++   insulin Zhou 2008
methotrexate 11602674 colchicine 11284688 cyproheptadine 11498864   lopinavir-chronic  12700464
midazolam 11602674 corticosteroids (Delph 2000) darunavir 18389894   methotrexate Zhou 2008
mirtazapine 8215618 cortisol 11966513 desethylamiodarone 11231118   mitoxantrone Zhou 2008
nifedipine 12406646 cyclosporine 11199931 desipramine  10408903   morphine Zhou 2008
ofloxacin dexamethasone  10831014 dexniguldipine 12021398   nefazodone 11452702, 12700464
?ranitidine 11602674 daunorubicin 11199931 dexrazoxane  11286477   nelfinavir Zhou 2008
sufentanil 11964599 debrisoquine 12406646 diltiazem 11497241   nevirapine  12180537
sumatriptan 11602674 dexamethasone 11199931 dipyridamole  11497241   nicardipine Zhou 2008
yohimbine 11602674 digoxin 11284449 disulfiram 14978246   nifedipine Zhou 2008
  digitoxin  11284449 doxazosin 11895100   paclitaxel 12489979
  diltiazem 11602674 elicridqr Zhou 2008   phenobarbital 12489979
  dipyridamole 11602674 emetine 11743742   phenothiazines Watkins
  docetaxel 11497241 erythromycin  11322768   phenytoin Zhou 2008
  domperidone 16364611 felodipine 10586385   prazosin Watkins
  doxepine 14550684 fenofibrate 14698041   probenecid Zhou 2008
  doxorubicin 11286477, 17722645 fentanyl 11964599   reserpine 12489979
  doxycycline Zhou 2008 flavonoids 11915946   retinoid acid Zhou 2008
  emetine Watkins fluoxetine  12649369,18851896   ritonavir (chronic)11745741
  enoxacin 10586385 fluphenazine 11199931, 11743742   rifampin  11297522
  epirubicin 11497241 fluvoxamine  12649369   St. John’s Wort 11739235
  erythromycin 11199931 fucidin 11497241   tacrolimus Zhou 2008
  estradiol 10586385 gallpamil 11743742   tamoxifen Zhou 2008
  etoposide  11290874 glyburide 10087141   trazodone 11452702
  fexofenadine 11240975 gramicidin D 11497241   verapamil Zhou 2008
  glyburide 11406737 grapefruit juice 11231102   vinblastine Zhou 2008
  gramicidin D 16364611 garlic 11466175   vincristine Zhou 2008
  grepafloxacin 11861816 green t ea (catechins) 11853888   yohimbine Zhou 2008
  hydrocortisone (10586385 ) haloperidol  10408903,17331325  
  imatinib 18449471 hydrocortisone 10586385    
  indinavir  11242145 hyroxyzine 11290874    
  irinotecan 11489791 josamycin 10901387    
  itraconazole 16364611 ketoconazole 11199931    
  ivermectin 18468555 imipramine  10408903    
  ketoconazole 16364611 itraconazole 10586385    
  LAAM 17690563 ivermectin Watkins    
  L-dopa Watkins ketoconazole Zhou 2008    
  lansoprazole 11770010 laniquidar Thomas H ++    
  levofloxacin 12406646 lansoprazole 11770010    
  loperamide 11199931 levothyroxin 12235446    
  lopinavir  16364611 lidocaine 10586385    
  losartan 12406646 loperamide 11964599    
  lovastatin (Delph 2000) lopinavir-acute  12700464, 12700464    
  maraviroc FDA 2008 meetings loratadine  11454724    
  methylprednisolone 12535574 lovastatin 11250868    
  mibefradil 10901697 maprotiline  10408903    
  mithramycin 12406646 mefloquine 11497241    
  mitomycin C 17722645 methadone 11408360    
  mitoxantrone 11497241 mibefradil 10901697    
  morphine 11964599 midazolam (Delph 2000)    
  nelfinavir 17591677 mitomycin C 11311122    
  nicardipine 18624680 nefazodone (acute)  11452702    
  nifedipine 18624680 nelfinavir (Delph 2000)    
  nizatidine 19319690 nicardipine 16364611    
  nortriptyline 12082591 nitrendipine Zhou 2008    
  olanazpine 18239278 nobilitin 11743742    
  ondansetron 11199931 norverapamil 11743742    
  paclitaxel 11199931, 17722645 omeprazole 11770010    
  paroxetine 17304149 orange juice-Seville 12095536    
  pentazocaine Zhou 2008 ofloxacin  11322768    
  phenobarbital Zhou 2008 paroxetine  12649369    
  phenytoin 11908747 pantoprazole 11770010    
  prednisolone  12379510 phenothiazines 11282269    
  progesterone 18624680 piperine 12130727    
  puromycin Watkins pimozide  11497241    
  quetiapine 12031686 probenecid  11322768    
  quinidine 12406646 progesterone 10586385    
  ranitidine  9862768 promethazine  11497241    
  rapamycin 10586385 propafenone  11497241    
  rifampin (Delph 2000) propranolol 11199931    
  risperidone 17337319 quercetin 12427482    
  ritonavir  11242145 quinacrine 16364611    
  saquinavir 17722645 quinidine 11199931    
  sertraline 18239278 quinine 11497241    
  sirolimus Zhou 2008 reserpine  11497241, 11743742    
  sparfloxacin 12406646 ritonavir (initial)10831014    
  tacrolimus  11303042 saquinavir 17365284    
  talinolol 11231102 sertraline 12649369    
  tamoxifen 17526937 simvastatin  11250868    
  taxol 9531522 spironolactone  11497241    
  teniposide 11497241, 17722645 sufentanil 11964599    
  terfenadine 11697207 tacrolimus Zhou 2008    
  tetracycline Zhou 2008 tamoxifen 10586385 ++    
  topiramate 12609264 tariquidar  Thomas H++    
  topotecan 11497241, 17975156 telithromycin 18027988    
  triamcinolone 16364611 terfenadine 10586385    
  trimipramine 18239278 testosterone Watkins    
  valinomycin 17722645 tetrabenzine Zhou 2008    
  valspodar Zhou 2008 thioridazine  7924890    
  vecuronium Zhou 2008 trifluoperazine  11497241    
  venlafaxine 16387324 trifluopromazine 11497241    
  verapamil 12535574 trimipramine  10408903    
  vinblastine  11303953 valinomycin  11497241, 11743742    
  vincristine 10586385 vanadate 12535574    
  vindesine 10586385 (venlafaxine)  12649369    
  vinorelbine  11497241 verapamil 11199931++    
  FK506 vinblastine 10586385    
    FK506 10586385    
    RU486(mifepristone) 10586385    
    Valspodar PSC 833 11249778++    
    zosuquidar Thomas H ++    
    2n-propylquinoline 12810046    

 

Legend
used clinically as a modulator ++
not a CYP3A4 inhibitor
number indicates PMID number in PubMed

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