Compiled By Jessica Oesterheld,
M.D.
This table is an abridged guide to UGTs. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.
Last Update: May 16, 2008
Click here for a print version
|
UGT1A1 |
UGT1A3 |
UGT1A4 |
UGT1A6 |
UGT1A9 |
UGT2B7 |
UGT2B15 |
Chromosome |
2 |
2 |
2 |
2 |
2 |
4 |
4 |
Genetic Variation |
yes |
yes |
yes |
yes |
yes |
yes |
yes |
Some Endogenous Substrates |
bilirubin |
estrones |
androsterone |
serotonin |
thyroxine |
androsterone |
dihydro-
testosterone |
|
estriol |
|
progestins |
|
|
bile acid |
|
|
|
|
|
|
|
|
|
Some Substrate
Drugs |
acetaminophen |
buprenorphine |
(amitriptyline) |
acetaminophen |
acetaminophen |
carbamazepine |
desloratadine |
|
buprenorphine |
(chlorpromazine) |
chlorpromazine |
phenytoin |
ethinyl estradiol |
ibuprofen |
s-oxazepam |
|
ethinyl estradiol |
(clozapine) |
clomipramine |
valproate |
ibuprofen |
lamotrigine |
s-lorazepam |
|
ibuprofen |
cyproheptadine |
clozapine |
|
phenytoin |
lorazepam |
|
|
irinotecan mb-SN-38 |
diphenydramine |
cyproheptadine |
|
valproate |
morphines |
|
|
nicotine |
doxepin |
diphenydramine |
|
warfarin |
propranolol |
|
|
phenytoin |
(ibuprofen) |
doxepin |
|
|
sertraline |
|
|
warfarin |
(valproate) |
imipramine |
|
|
valproate |
|
|
|
|
lamotirigne |
|
|
zidovudine |
|
|
|
|
loxapine |
|
|
|
|
|
|
|
olanzapine |
|
|
|
|
|
|
|
phenytoin |
|
|
|
|
|
|
|
trifluoperazine |
|
|
|
|
|
|
|
|
|
|
|
|
Possible Inducers |
dexamethasone |
|
carbamazepine |
dexamethasone |
phenobarbital |
phenobarbital |
|
|
phenobarbital |
|
ethinyl estradiol |
|
|
phenytoin |
|
|
phenytoin |
|
(oxcarbamazepine) |
|
|
rifampin |
|
|
|
|
phenobarbital |
|
|
|
|
|
|
|
phenytoin |
|
|
|
|
|
|
|
rifampin |
|
|
|
|
|
|
|
|
|
|
|
|
Possible Inhibitors |
ketoconazole |
imipramine |
probenecid |
probenecid |
probenecid |
codeine |
ibuprofen |
|
probenecid |
probenecid |
|
|
ketoconazole |
diazepam |
ketoconazole |
|
|
|
|
|
valproate |
ketoconazole |
probenecid |
|
|
|
|
|
|
morphine |
valproate |
|
|
|
|
|
|
probenecid
|
|
|
|
|
|
|
|
valproate |
|
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