UDP glucuronosyltransferase (UGT) Reference Table

Compiled By Jessica Oesterheld, M.D.

This table is an abridged guide to UGTs. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

Last Update: May 16, 2008
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UGT1A1

UGT1A3

UGT1A4

UGT1A6

UGT1A9

UGT2B7

UGT2B15

Chromosome

2 2 2 2 2 4 4

Genetic Variation

yes yes yes yes yes yes yes

Some Endogenous Substrates

bilirubin estrones androsterone serotonin thyroxine androsterone dihydro-
testosterone

estriol progestins bile acid

Some Substrate
Drugs

acetaminophen buprenorphine (amitriptyline) acetaminophen acetaminophen carbamazepine desloratadine

buprenorphine (chlorpromazine) chlorpromazine phenytoin ethinyl estradiol ibuprofen s-oxazepam

ethinyl estradiol (clozapine) clomipramine valproate ibuprofen lamotrigine s-lorazepam

ibuprofen cyproheptadine clozapine phenytoin lorazepam

irinotecan mb-SN-38 diphenydramine cyproheptadine valproate morphines

nicotine doxepin diphenydramine warfarin propranolol

phenytoin (ibuprofen) doxepin sertraline

warfarin (valproate) imipramine valproate

lamotirigne zidovudine

loxapine

olanzapine

phenytoin

trifluoperazine

Possible Inducers

dexamethasone carbamazepine dexamethasone phenobarbital phenobarbital

phenobarbital ethinyl estradiol phenytoin

phenytoin (oxcarbamazepine) rifampin

phenobarbital

phenytoin

rifampin

Possible Inhibitors

ketoconazole imipramine probenecid probenecid probenecid codeine ibuprofen

probenecid probenecid ketoconazole diazepam ketoconazole

valproate ketoconazole probenecid

morphine valproate

probenecid

valproate

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