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UDP glucuronosyltransferase (UGT) Reference Table

Compiled By Jessica Oesterheld, M.D.

This table is an abridged guide to UGTs. To appreciate the full benefits of this information, click here to get a free 30-day trial version of GeneMedRx. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

Last Update: May 16, 2008
Click here for a print version

UGT1A1

UGT1A3

UGT1A4

UGT1A6

UGT1A9

UGT2B7

UGT2B15

Chromosome

2 2 2 2 2 4 4

Genetic Variation

yes yes yes yes yes yes yes

Some Endogenous Substrates

bilirubin estrones androsterone serotonin thyroxine androsterone dihydro-
testosterone

estriol   progestins     bile acid  

             

Some Substrate
Drugs

acetaminophen buprenorphine (amitriptyline) acetaminophen acetaminophen carbamazepine desloratadine

buprenorphine (chlorpromazine) chlorpromazine phenytoin ethinyl estradiol ibuprofen s-oxazepam

ethinyl estradiol (clozapine) clomipramine valproate ibuprofen lamotrigine s-lorazepam

ibuprofen cyproheptadine clozapine   phenytoin lorazepam  

irinotecan mb-SN-38 diphenydramine cyproheptadine   valproate morphines  

nicotine doxepin diphenydramine   warfarin propranolol  

phenytoin (ibuprofen) doxepin     sertraline  

warfarin (valproate) imipramine     valproate  

    lamotirigne     zidovudine  

    loxapine        

    olanzapine        

    phenytoin        

    trifluoperazine        

             

Possible Inducers

dexamethasone   carbamazepine dexamethasone phenobarbital phenobarbital  

phenobarbital   ethinyl estradiol     phenytoin  

phenytoin   (oxcarbamazepine)     rifampin  

    phenobarbital        

    phenytoin        

    rifampin        

             

Possible Inhibitors

ketoconazole imipramine probenecid probenecid probenecid codeine ibuprofen

probenecid probenecid     ketoconazole diazepam ketoconazole

        valproate ketoconazole probenecid

          morphine valproate

          probenecid
 

          valproate  

GeneMedRx has not been reviewed or approved by the United States Food and Drug Administration and cannot be used to diagnose or treat any disease or other health condition.

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